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A meta-analysis of nine randomised trials in 591 women with PCOS found significant reductions in HOMA-IR, total cholesterol, and triglycerides, with no clear effect on luteinising hormone, total testosterone, or sex hormone binding globulin

Intramuscular administration bypasses oral absorption, which is limited to approximately 12% of dose above 1,000 mcg due to intrinsic factor saturation in the ileum

A baseline group was included, which was injected with vehicle 6 h prior to sacrifice

Given that exercise and tDCS share common neural substrates, it is hypothesised that combining these techniques produces synergistic effects, yielding cognitive enhancement outcomes superior to those of single interventions